一种亲电策略用于钯催化的杂环羰基化 C-H 功能化反应。
An Electrophilic Approach to the Palladium-Catalyzed Carbonylative C-H Functionalization of Heterocycles.
机构信息
Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada.
出版信息
J Am Chem Soc. 2015 Sep 23;137(37):12050-4. doi: 10.1021/jacs.5b07098. Epub 2015 Sep 14.
A palladium-catalyzed approach to intermolecular carbonylative C-H functionalization is described. This transformation is mediated by P(t)Bu3-coordinated palladium catalyst and allows the derivatization of a diverse range of heterocycles, including pyrroles, indoles, imidazoles, benzoxazoles, and furans. Preliminary studies suggest that this reaction may proceed via the catalytic formation of highly electrophilic intermediates. Overall, this provides with an atom-economical and general synthetic route to generate aryl-(hetero)aryl ketones using stable reagents (aryl iodides and CO) and without the typical need to exploit pre-metalated heterocycles in carbonylative coupling chemistry.
本文描述了一种钯催化的分子间羰基化 C-H 官能化方法。这种转化由 P(t)Bu3 配位的钯催化剂介导，并允许对各种杂环进行衍生化，包括吡咯、吲哚、咪唑、苯并恶唑和呋喃。初步研究表明，该反应可能通过催化形成高反应性的中间体进行。总的来说，该方法使用稳定的试剂（芳基碘化物和 CO），并且无需在羰基偶联化学中典型地利用预金属化杂环，为生成芳基-（杂）芳基酮提供了一种原子经济性和通用的合成途径。
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