在生态友好型溶剂2-甲基四氢呋喃中，通过芳基格氏试剂与酰氯在温和条件下偶联，连续流动合成二芳基酮。
Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran.
作者信息
Zhang Chuan-Tao, Zhu Rui, Wang Zheng, Ma Bing, Zajac Adrian, Smiglak Marcin, Xia Chun-Nian, Castle Steven L, Wang Wen-Long
机构信息
School of Pharmaceutical Science, Jiangnan University Wuxi 214122 China
Hybrid-Chem Technologies Shanghai 201203 China.
出版信息
RSC Adv. 2019 Jan 17;9(4):2199-2204. doi: 10.1039/c8ra07447j. eCollection 2019 Jan 14.
An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived "green" solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour.
通过在生物衍生的“绿色”溶剂2-甲基四氢呋喃（2-MeTHF）中，在温和的反应条件下（环境温度，1小时），使芳基格氏试剂与酰氯偶联，实现了二芳基酮的高效连续流动顺序合成，能够安全且按需生成2-(3-苯甲酰基苯基)丙腈，生产率为3.16克/小时。
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