用于检测肉毒杆菌毒素和蓖麻毒素的电化学适体支架生物传感器。
Electrochemical aptamer scaffold biosensors for detection of botulism and ricin toxins.
作者信息
Fetter Lisa, Richards Jonathan, Daniel Jessica, Roon Laura, Rowland Teisha J, Bonham Andrew J
机构信息
Department of Chemistry, Metropolitan State University of Denver, Denver, CO 80204, USA.
出版信息
Chem Commun (Camb). 2015 Oct 21;51(82):15137-40. doi: 10.1039/c5cc05933j. Epub 2015 Sep 1.
Protein toxins present considerable health risks, but detection often requires laborious analysis. Here, we developed electrochemical aptamer biosensors for ricin and botulinum neurotoxins, which display robust and specific signal at nanomolar concentrations and function in dilute serum. These biosensors may aid future efforts for the rapid diagnosis of toxins.
蛋白质毒素存在相当大的健康风险，但检测往往需要繁琐的分析。在此，我们开发了用于蓖麻毒素和肉毒杆菌神经毒素的电化学适体生物传感器，它们在纳摩尔浓度下显示出强大且特异的信号，并能在稀释血清中发挥作用。这些生物传感器可能有助于未来毒素快速诊断的研究工作。
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