简单的食物分流手术是2型糖尿病治疗的解决方案吗？在非肥胖大鼠模型中的实验研究。
Is a Simple Food-Diverting Operation the Solution for Type 2 Diabetes Treatment? Experimental Study in a Non-Obese Rat Model.
作者信息
Melissas John, Peirasmakis Drakos, Lamprou Vasileios, Papadakis John
机构信息
Bariatric Unit, Department of Surgical Oncology, University of Crete, 164 Erythreas str, Heraklion, 71409, Greece.
Department of Medicine, Heraklion University Hospital, Medical School, University of Crete, Heraklion, Greece.
出版信息
Obes Surg. 2016 May;26(5):1010-5. doi: 10.1007/s11695-015-1871-8.
BACKGROUND
The feasibility of a side-to-side jejunoileal anastomosis (SJA) to control type 2 diabetes mellitus (T2DM) was studied in non-obese diabetic Goto-Kakizaki (GK) rats.
METHODS
Seventeen 14-week-old male GK rats were divided into three groups: SJA bypassing 60% of the small bowel length, sham-operated jejunoileal bypass (Sham group), and control animals. Rats were observed for 10 weeks after surgery. Fasting blood glucose (FBG) levels and oral glucose tolerance test (OGTT) were measured before and after the procedure.
RESULTS
Animals with SJA exhibited normalization of FBG levels from the 1st and up to the 10th postoperative week when the experiment terminated. OGTT compared with sham-operated and control groups was also significantly better at 3 and 8 weeks postoperatively.
CONCLUSIONS
A simple SJA, diverting the food and biliopancreatic secretion to the distal small bowel, was able to normalize both FBG levels and OGTT in a non-obese diabetic rat model.
背景
在非肥胖型糖尿病Goto-Kakizaki（GK）大鼠中研究了侧侧空肠回肠吻合术（SJA）控制2型糖尿病（T2DM）的可行性。
方法
将17只14周龄雄性GK大鼠分为三组：绕过60%小肠长度的SJA组、假手术空肠回肠旁路组（假手术组）和对照组动物。术后观察大鼠10周。在手术前后测量空腹血糖（FBG）水平和口服葡萄糖耐量试验（OGTT）。
结果
SJA组动物在术后第1周直至实验结束的第10周，FBG水平恢复正常。术后3周和8周时，与假手术组和对照组相比，OGTT也明显更好。
结论
一种简单的SJA，即将食物和胆胰分泌物转移至远端小肠，能够使非肥胖型糖尿病大鼠模型的FBG水平和OGTT恢复正常。
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