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Failure of reversal of cardiovascular responses of clonidine by centrally administered naloxone in anaesthetised rats.

作者信息

Srivastava R K, Kaur A H

出版信息

Indian J Exp Biol. 1989 Jul;27(7):628-30.

PMID:2632389
Abstract

Central effects of naloxone on the cardiovascular responses of centrally administered clonidine were studied in anaesthetised normotensive, renal DOCA-salt hypertensive and morphine dependent rats. Clonidine (5 micrograms/ICV) produced significant decrease in blood pressure and heart rate in all the groups of rats in a dose dependent manner. Naloxone (2 micrograms/ICV) failed to reverse the responses of clonidine in all the rat groups. In morphine dependent normotensive and morphine dependent renal DOCA-salt hypertensive rats, the responses of clonidine were further enhanced in the presence of naloxone. Our observations clearly indicate that clonidine does not influence endogenous opioid system for producing cardiovascular effects.

摘要

相似文献

1
Failure of reversal of cardiovascular responses of clonidine by centrally administered naloxone in anaesthetised rats.
Indian J Exp Biol. 1989 Jul;27(7):628-30.
2
No evidence for involvement of endogenous opioid peptides in effects of clonidine on blood pressure, heart rate and plasma norepinephrine in anesthetized rats.
J Pharmacol Exp Ther. 1984 Jun;229(3):803-8.
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Role of opioidergic component in the antihypertensive effect of clonidine.阿片能成分在可乐定降压作用中的作用。
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Failure of naloxone to reduce clonidine-induced changes in blood pressure, heart rate and sympathetic nerve firing in cats.纳洛酮未能降低可乐定引起的猫血压、心率及交感神经放电的变化。
J Pharmacol Exp Ther. 1983 Mar;224(3):494-500.
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Intrathecal morphine and clonidine: antinociceptive tolerance and cross-tolerance and effects on blood pressure.鞘内注射吗啡和可乐定：抗伤害感受性耐受和交叉耐受以及对血压的影响。
J Pharmacol Exp Ther. 1988 May;245(2):444-54.
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Antihypertensive effects of a new transdermal delivery system for clonidine in genetic and experimental hypertensive rats.可乐定新型透皮给药系统对遗传性和实验性高血压大鼠的降压作用
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On the relationship between clonidine hypotension and brain beta-endorphin in the spontaneously hypertensive rat: studies with alpha adrenergic and opiate blockers.自发性高血压大鼠可乐定低血压与脑β-内啡肽的关系：α肾上腺素能阻滞剂和阿片受体阻滞剂的研究
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[Blocking by naloxone of the antihypertensive effect of clonidine in hypertensive and normotensive animals].[纳洛酮对可乐定在高血压和正常血压动物中降压作用的阻断]
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