Wu Yueming, Chen Yipeng, Liu Hong, Zou Suhua
Department of Intensive Care Unit, The People's Hospital of Lishui, Lishui 323000, PR China.
J Cancer Res Ther. 2015 Aug;11 Suppl 1:C115-7. doi: 10.4103/0973-1482.163863.
The objective of this study is to investigate the risk factors for developing postthymectomy myasthenic crisis in thymoma patients.
Patients with thymoma received thymectomy from January 2001 to December 2014 were reviewed and included in this retrospective study in Lishui People's Hospital. Seventy-seven patients were included in this study. For the 77 cases, 66 patients not developing postthymectomy myasthenic crisis were considered as a control group, and other 11 subjects developing postthymectomy myasthenic were considered as the case group. The potential risk factors such age, gender, Osseman stage, Masaoka, pyridostigmine bromide, and et al. were compared between case and control group firstly by Chi-square test or Student's t-test and then by logistic regression test.
Eleven patients developed postthymectomy myasthenic with the incidence of 14.3%; logistic regression analysis indicates that pyridostigmine bromide >360 mg/day administration (OR = 21.2, P < 0.05), postsurgery pulmonary infection (OR = 8.3, P < 0.05) and myasthenic crisis prior surgery (OR = 3.2, P < 0.05) were the independent risk factors for developing postthymectomy myasthenic crisis in thymoma patients.
Thymoma patients with a large dosage of pyridostigmine bromide administration, postsurgery pulmonary infection and myasthenic crisis prior surgery were easy to have postthymectomy myasthenic crisis.
本研究旨在探讨胸腺瘤患者胸腺切除术后发生肌无力危象的危险因素。
回顾性分析2001年1月至2014年12月在丽水市人民医院接受胸腺切除术的胸腺瘤患者。本研究共纳入77例患者。其中，66例未发生胸腺切除术后肌无力危象的患者作为对照组，11例发生胸腺切除术后肌无力危象的患者作为病例组。首先通过卡方检验或学生t检验比较病例组和对照组之间年龄、性别、 Osseman分期、Masaoka分期、溴吡斯的明等潜在危险因素，然后进行逻辑回归检验。
11例患者发生胸腺切除术后肌无力危象，发生率为14.3%；逻辑回归分析表明，溴吡斯的明每日用量>360mg（OR = 21.2，P < 0.05）、术后肺部感染（OR = 8.3，P < 0.05）和术前肌无力危象（OR = 3.2，P < 0.05）是胸腺瘤患者发生胸腺切除术后肌无力危象的独立危险因素。
溴吡斯的明用量大、术后肺部感染和术前肌无力危象的胸腺瘤患者易发生胸腺切除术后肌无力危象。
