记忆性T细胞激活与有效免疫的机制
Mechanisms of Memory T Cell Activation and Effective Immunity.
作者信息
Lauvau Grégoire, Soudja Saïdi M'Homa
机构信息
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA,
出版信息
Adv Exp Med Biol. 2015;850:73-80. doi: 10.1007/978-3-319-15774-0_6.
Abstract
Effective immunization induces the development of populations of robust effector lymphocytes specific for the immunizing antigens. Amongst them are cytotoxic/CD8(+)T lymphocytes, which few will further differentiate into long-lived memory cells persisting in the host and exhibiting improved functional characteristics. The current model is that such memory cells can confer rapid host protection upon cognate antigen-mediated activation and direct killing of infected cells. In this chapter, we discuss work from our group and others that highlight the contribution of inflammatory cytokines to memory CD8(+) T cell activation and of cytolysis-independent mechanisms of host protection.
摘要
有效的免疫接种可诱导针对免疫抗原的强大效应淋巴细胞群体的发育。其中包括细胞毒性/CD8(+)T淋巴细胞，少数此类细胞会进一步分化为长期存在于宿主体内并具有改善功能特性的长寿记忆细胞。目前的模型认为，此类记忆细胞可在同源抗原介导的激活以及对感染细胞的直接杀伤作用下为宿主提供快速保护。在本章中，我们将讨论我们团队以及其他团队的研究工作，这些工作突出了炎性细胞因子对记忆性CD8(+)T细胞激活的作用以及宿主保护的非细胞溶解机制。
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