Hunziker D, Schlumpf R, Decurtins M, Keusch G, Largiadèr F
Helv Chir Acta. 1989 Dec;56(4):543-7.
Thrombosis of the pancreas transplant is one of the main causes for the lower success rate of this procedure compared with that of other organ transplantations. Approximately one quarter of the pancreas transplantations discussed in this study are unsuccessful for this reason. This work is a retrospective study focusing on the postoperative blood platelet counts from 19 patients with a combined pancreas and kidney transplant, functioning well for at least 1.5 months. 19 patients with only a kidney transplantation with similar distribution of sex, age and postoperative immunosuppressive treatment were observed as a control group. After pancreas transplantation the platelet counts increased considerably and were found to be far above the normal level. There are no proven pathophysiological explanations for this thrombocytosis. Because of an increased risk of thrombosis, we recommend to use platelet inhibitors during the first two postoperative months.
胰腺移植血栓形成是该手术成功率低于其他器官移植的主要原因之一。本研究中讨论的胰腺移植约有四分之一因此未获成功。这项工作是一项回顾性研究，重点关注19例胰肾联合移植患者术后的血小板计数，这些患者移植功能良好至少达1.5个月。观察19例仅接受肾移植、性别、年龄及术后免疫抑制治疗分布相似的患者作为对照组。胰腺移植后血小板计数显著增加，且远高于正常水平。目前尚无关于这种血小板增多症的确证病理生理学解释。由于血栓形成风险增加，我们建议在术后头两个月使用血小板抑制剂。
