Russo D, Fraser R, Kenyon C J
MRC Blood Pressure Unit, Western Infirmary, Glasgow, UK.
J Hypertens Suppl. 1989 Dec;7(6):S126-7. doi: 10.1097/00004872-198900076-00059.
We studied the effects of dexamethasone on the vascular responsiveness of the isolated perfused mesenteric vascular bed of the rats. Dexamethasone was infused at a low dose (2 micrograms/day) to avoid steroid-induced catabolic effects. The mesenteric arteries were perfused with increasing concentrations of noradrenaline, vasopressin and potassium chloride. Vascular responses to vasopressin and potassium chloride were similar in both dexamethasone-treated and control arteries. However, the dexamethasone treatment increased the sensitivity, but not the maximal pressor response, to noradrenaline. These results show that dexamethasone selectively increases the vascular sensitivity to noradrenaline in rats before the development of systemic hypertension.
我们研究了地塞米松对大鼠离体灌注肠系膜血管床血管反应性的影响。以低剂量（2微克/天）输注地塞米松以避免类固醇诱导的分解代谢效应。用浓度递增的去甲肾上腺素、血管加压素和氯化钾灌注肠系膜动脉。地塞米松处理组和对照组动脉对血管加压素和氯化钾的血管反应相似。然而，地塞米松处理增加了对去甲肾上腺素的敏感性，但未增加最大升压反应。这些结果表明，在系统性高血压发生之前，地塞米松可选择性增加大鼠血管对去甲肾上腺素的敏感性。
