Kraft K, Kokorsch F, Diehl J, Kolloch R, Stumpe K O
Medizinische Poliklinik, Bonn, Federal Republic of Germany.
J Hypertens Suppl. 1989 Dec;7(6):S18-9. doi: 10.1097/00004872-198900076-00006.
Leucine-enkephalin is known to modulate cardiovascular activity. In the present study we determined plasma leucine-enkephalin and noradrenaline concentrations in young men with essential hypertension and in normotensives at rest and after bicycle exercise. The essential hypertensive patients had a lower concentration level of resting leucine-enkephalin than the normotensives. Exercise increased leucine-enkephalin in both groups. Noradrenaline was significantly higher in the essential hypertensives than in the normotensives. The central alpha 2-agonist clonidine reduced leucine-enkephalin at rest in the normotensives and prevented its increase during exercise, but had no effect on leucine-enkephalin in the essential hypertensives. These results may reflect an altered interaction between leucine-enkephalin and noradrenaline in essential hypertensives compared to normotensives, possibly contributing to hypertension.
已知亮氨酸脑啡肽可调节心血管活动。在本研究中，我们测定了原发性高血压青年男性和血压正常者在静息状态及自行车运动后的血浆亮氨酸脑啡肽和去甲肾上腺素浓度。原发性高血压患者静息时亮氨酸脑啡肽的浓度水平低于血压正常者。运动使两组的亮氨酸脑啡肽水平均升高。原发性高血压患者的去甲肾上腺素水平显著高于血压正常者。中枢α2受体激动剂可乐定可降低血压正常者静息时的亮氨酸脑啡肽水平，并阻止其在运动时升高，但对原发性高血压患者的亮氨酸脑啡肽水平无影响。这些结果可能反映出与血压正常者相比，原发性高血压患者体内亮氨酸脑啡肽和去甲肾上腺素之间的相互作用发生了改变，这可能是导致高血压的原因之一。
