Del Bo A, Marabini M, Aghemo A, Zanchetti A
Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy.
J Hypertens Suppl. 1989 Dec;7(6):S200-1. doi: 10.1097/00004872-198900076-00096.
Hypertonic saline (100 mmol in 50 ml) was injected intravenously over 5 min in two groups of moderate essential hypertensive patients (group 1, n = 13; group 2, n = 6). In group 2, arterial pressure had been lowered by infusion of clonidine (0.3 mg in 100 ml saline), from 186 +/- 8/116 +/- 3 to 146 +/- 9/98 +/- 5 mmHg (mean +/- s.e.m.). The hypertonic stimulus increased the plasma osmolality of all subjects from 288 +/- 1 to 296 +/- 1 mosmol/kg (P less than 0.01). Plasma vasopressin increased from baseline values that were not significantly different (P less than 0.01) in each of the two groups. The increase in plasma vasopressin was significantly greater (P less than 0.05) in the group 2 hypertensives with a reduced arterial pressure (+7.81 +/- 1.79 pg/ml) than in the group 1 untreated hypertensives (+3.15 +/- 1.2 pg/ml). In our study, acute lowering of arterial pressure by clonidine did not significantly change baseline vasopressin, but facilitated osmotically induced vasopressin secretion.
对两组中度原发性高血压患者（第1组，n = 13；第2组，n = 6）在5分钟内静脉注射高渗盐水（50 ml含100 mmol）。在第2组中，通过输注可乐定（100 ml盐水中含0.3 mg），动脉压从186±8/116±3 mmHg降至146±9/98±5 mmHg（均值±标准误）。高渗刺激使所有受试者的血浆渗透压从288±1 mosmol/kg升高至296±1 mosmol/kg（P<0.01）。两组患者血浆血管加压素均从基线值升高（P<0.01），且升高幅度无显著差异。第2组血压降低的高血压患者（升高7.81±1.79 pg/ml）血浆血管加压素升高幅度显著大于第1组未治疗的高血压患者（升高3.15±1.2 pg/ml）（P<0.05）。在我们的研究中，可乐定急性降低动脉压并未显著改变基线血管加压素水平，但促进了渗透压诱导的血管加压素分泌。
