毛细血管干血斑是否适用于常见抗精神病药物的治疗药物监测？概念验证。
Are capillary DBS applicable for therapeutic drug monitoring of common antipsychotics? A proof of concept.
作者信息
Patteet Lisbeth, Maudens Kristof E, Stove Christophe P, Lambert Willy E, Morrens Manuel, Sabbe Bernard, Neels Hugo
机构信息
Toxicological Centre, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
Laboratory for TDM & Toxicology, ZNA Stuivenberg, Lange Beeldekensstraat 267, B-2060 Antwerp, Belgium.
出版信息
Bioanalysis. 2015;7(16):2119-30. doi: 10.4155/bio.15.100.
AIM
DBS sampling has been proposed as an alternative for venous blood collection in therapeutic drug monitoring (TDM) of antipsychotics. For implementation in routine practice, a comparison between capillary and venous blood concentrations is mandatory.
RESULTS
A DBS method for quantification of antipsychotics was clinically validated. First, whole blood therapeutic ranges were calculated using the blood:serum ratio. Calculation of DBS:blood ratios and Passing-Bablok regression analysis demonstrated that concentrations obtained by DBS analysis were highly comparable to those obtained by conventional whole blood analysis. Clinical interpretation of serum, whole blood and DBS concentrations were highly identical (sensitivity 91.6-97.6%).
CONCLUSION
This is the first clinical study demonstrating the value of DBS sampling in TDM of antipsychotics.
目的
在抗精神病药物治疗药物监测（TDM）中，已提出采用干血斑（DBS）采样作为静脉采血的替代方法。为了在常规实践中实施，必须对毛细血管血和静脉血浓度进行比较。
结果
一种用于抗精神病药物定量的DBS方法已通过临床验证。首先，使用血液：血清比率计算全血治疗范围。DBS：血液比率的计算和Passing-Bablok回归分析表明，DBS分析获得的浓度与传统全血分析获得的浓度高度可比。血清、全血和DBS浓度的临床解释高度一致（敏感性为91.6-97.6%）。
结论
这是第一项证明DBS采样在抗精神病药物TDM中的价值的临床研究。
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