Hannedouche T, Delgado A, Schmidt F, Gnionsahé A, Lacour B, Grünfeld J P
Département de Néphrologie, Hôpital Necker, Paris, France.
J Hypertens Suppl. 1989 Dec;7(6):S282-3. doi: 10.1097/00004872-198900076-00137.
In 12 newly diagnosed normotensive insulin-dependent diabetics and eight controls, we compared the effects of acute nicardipine administration on renal haemodynamics and segmental tubular movement of sodium assessed as by lithium clearances. Both in the controls and the insulin-dependent diabetics, nicardipine induced similar haemodynamic changes, including a mild decrease in mean arterial pressure and renal vascular resistance, whereas the glomerular filtration, renal plasma flow and filtration fraction were unchanged. Despite a fall in blood pressure, nicardipine exerted a marked natriuretic effect in both groups, which appears to have been primarily due to a decrease in distal reabsorption and, to a lesser extent, in proximal reabsorption.
在12例新诊断的血压正常的胰岛素依赖型糖尿病患者和8例对照者中，我们比较了急性给予尼卡地平对肾血流动力学以及通过锂清除率评估的钠在肾小管各节段转运的影响。在对照组和胰岛素依赖型糖尿病患者中，尼卡地平引起的血流动力学变化相似，包括平均动脉压和肾血管阻力轻度降低，而肾小球滤过率、肾血浆流量和滤过分数未改变。尽管血压下降，但尼卡地平在两组中均发挥了显著的利钠作用，这似乎主要是由于远端重吸收减少，近端重吸收减少的程度较小。
