Alvarez-Cubero Maria Jesus, Pascual-Geler Manrique, Rivas Ana, Martinez-Gonzalez Luis Javier, Saiz Maria, Lorente Jose Antonio, Cozar Jose Manuel
a Laboratory of Genetic Identification , Legal Medicine and Toxicology Department, Faculty of Medicine, University of Granada , Granada , Spain .
b GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research) , Granada , Spain .
Int J Food Sci Nutr. 2015;66(7):805-10. doi: 10.3109/09637486.2015.1077786. Epub 2015 Aug 28.
The aim of the present study was to determine the association between the socio-demographic, lifestyle factors, and dietary habits with the risk of prostate cancer (PC) in a case-control study of Spanish men. None of the socio-demographic, lifestyle or dietetic variables was found predictors of PC risk. Body mass index was associated with an increased risk for aggressive PC and fruit consumption with lower Gleason scores, thus less aggressive cancers. Nonetheless, after applying Bonferroni correction, these variables were not still associated with PC aggressiveness. More adequately, powered epidemiological studies that measure the effect of lifestyle and dietary intake in PC risk and aggressiveness are warranted to further elucidate the role of these modifiable factors on PC etiology.
本研究的目的是在一项针对西班牙男性的病例对照研究中,确定社会人口统计学、生活方式因素和饮食习惯与前列腺癌(PC)风险之间的关联。未发现任何社会人口统计学、生活方式或饮食变量是PC风险的预测因素。体重指数与侵袭性PC风险增加相关,而水果摄入量与较低的Gleason评分相关,因此癌症侵袭性较低。尽管如此,在应用Bonferroni校正后,这些变量仍与PC侵袭性无关。更确切地说,需要有足够样本量的流行病学研究来衡量生活方式和饮食摄入对PC风险和侵袭性的影响,以进一步阐明这些可改变因素在PC病因学中的作用。