非肿瘤性乳腺实质的组织病理学特征不能预测浸润性乳腺癌患者的BRCA突变状态。
Histopathological Features of Non-Neoplastic Breast Parenchyma Do Not Predict BRCA Mutation Status of Patients with Invasive Breast Cancer.
作者信息
Bayraktar Soley, Qiu Hongming, Liu Diane, Shen Yu, Gutierrez-Barrera Angelica M, Arun Banu K, Sahin Aysegul A
机构信息
Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Biomark Cancer. 2015 Aug 18;7:39-49. doi: 10.4137/BIC.S29716. eCollection 2015.
BACKGROUND
Several studies have evaluated histologic features of non-neoplastic breast parenchyma in patients with BRCA1/2 mutations, but the results are conflicting. The limited data suggest a much higher prevalence of high-risk precursor lesions in BRCA carriers. Therefore, we designed this study to compare the clinicopathological characteristics of peritumoral benign breast tissue in patients with and without deleterious BRCA mutations.
METHODS
Women with breast cancer (BC) who were referred for genetic counseling and underwent BRCA genetic testing in 2010 and 2011 were included in the study.
RESULTS
Of the six benign histological features analyzed in this study, only stromal fibrosis grade 2/3 was found to be statistically different, with more BRCA noncarriers having stromal fibrosis grade 2/3 than BRCA1/2 carriers (P = 0.04).
CONCLUSION
There is no significant association between mutation risk and the presence of benign histologic features of peritumoral breast parenchyma.
背景
多项研究评估了携带BRCA1/2突变患者非肿瘤性乳腺实质的组织学特征，但结果相互矛盾。有限的数据表明BRCA携带者中高危前驱病变的患病率要高得多。因此，我们设计了本研究，以比较有和没有有害BRCA突变的患者瘤周良性乳腺组织的临床病理特征。
方法
纳入2010年和2011年因遗传咨询转诊并接受BRCA基因检测的乳腺癌女性患者。
结果
在本研究分析的六种良性组织学特征中，仅发现2/3级间质纤维化在统计学上存在差异，BRCA非携带者中2/3级间质纤维化的比例高于BRCA1/2携带者（P = 0.04）。
结论
突变风险与瘤周乳腺实质良性组织学特征的存在之间无显著关联。
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