Bolat Özgür, Erhan Elvan, Deniz Mustafa Nuri
Department of Anaesthesiology and Reanimation, Faculty of Medicine, Ege University, İzmir, Turkey.
Turk J Urol. 2013 Sep;39(3):175-80. doi: 10.5152/tud.2013.036.
The aim of this prospective double-blind randomized study was to compare the effectiveness of preoperative dexketoprofen trometamol for acute postoperative pain in patients undergoing minor outpatient urologic surgery.
Sixty male patients (ASA I and II) undergoing varicocelectomy and testicular sperm extraction (TESE) with standard laryngeal mask airway (LMA) anesthesia were randomly divided into two groups. Patients in Group I (n=30) received 50 mg of dexketoprofen trometamol iv before induction, whereas patients in Group II (n=30) received saline. All patients received standard LMA anesthesia (propofol, sevoflurane and N2O/O2). Analgesic efficacy was evaluated by self-assessment of pain intensity (VAS) at regular intervals. Vital signs, side effects and time to reach a postanesthesia discharge score (PADS) of ≥9 were also recorded. Paracetamol 1 gr iv and tramadol 100 mg iv were used for rescue analgesia.
Demographic data and duration of surgery were similar in both groups. There was no significant difference between groups with respect to postoperative pain scores and side effects. Although more patients in Group II (60%) required rescue analgesia compared to Group I (33.3%), the difference did not reach statistical significance.
Preoperative IV use of dexketoprofen trometamol iv did not decrease the need for rescue analgesia in patients undergoing minor outpatient urological surgery.
这项前瞻性双盲随机研究的目的是比较术前使用右酮洛芬氨丁三醇对接受门诊小泌尿外科手术患者术后急性疼痛的疗效。
60例接受精索静脉曲张切除术和睾丸精子提取术（TESE）并采用标准喉罩气道（LMA）麻醉的男性患者（ASA I和II级）被随机分为两组。第一组（n = 30）患者在诱导前静脉注射50 mg右酮洛芬氨丁三醇，而第二组（n = 30）患者接受生理盐水。所有患者均接受标准LMA麻醉（丙泊酚、七氟醚和N2O/O2）。通过定期自我评估疼痛强度（视觉模拟评分法，VAS）来评估镇痛效果。还记录了生命体征、副作用以及达到麻醉后出院评分（PADS）≥9分的时间。静脉注射1 g对乙酰氨基酚和100 mg曲马多用于补救镇痛。
两组的人口统计学数据和手术时间相似。两组在术后疼痛评分和副作用方面无显著差异。尽管与第一组（33.3%）相比，第二组中有更多患者（60%）需要补救镇痛，但差异未达到统计学意义。
对于接受门诊小泌尿外科手术的患者，术前静脉使用右酮洛芬氨丁三醇并不能减少补救镇痛的需求。
