Ma Shaohua, Lan Fang, Yang Qi, Xie Liqin, Wu Yao, Gu Zhongwei
J Nanosci Nanotechnol. 2015 Jan;15(1):349-54. doi: 10.1166/jnn.2015.8773.
Uniform superparamagnetic Fe3O4/poly(methyl methacrylate-acrylic acid) (P(MMA-AA)) composite nanoparticles with high saturation magnetization and good hydrophilicity were successfully and directly synthesized via a facile one-pot miniemulsion polymerization approach. The mixture of the ferrofluids, MMA and AA monomers, surfactants and initiator was co-sonicated and emulsified to prepare stable miniemulsion for polymerization. The as-prepared products were characterized by SEM, TEM, FT-IR, XRD, TGA and VSM. The results of SEM indicated that the morphology of the Fe3O4/P(MMA-AA) composite nanoparticles all assumed near spherical geometry with diameters about 60 nm, 60 nm, and 100 nm respectively corresponding to the weight ratios of Fe3O4 to MMA and AA at 1:8, 1:4, and 1:2. The TEM images implied that the Fe3O4/P(MMA-AA) composite nanoparticles showed a perfect core-shell structure with a polymeric shell of about 2 nm thickness and a core encapsulating uniform and close packed Fe3O4 nanoparticles. TGA and VSM showed that the Fe3O4/P(MMA-AA) composite nanoparticles with a maximum saturation magnetization up to 45 emu g(-1) corresponding to the magnetite content of 78% exhibited superparamagntism. The hydrophilic modification and the high saturation magnetization impart a promising potential for biomedical applications to the as-synthesized composite nanoparticles.
通过简便的一锅法微乳液聚合方法，成功直接合成了具有高饱和磁化强度和良好亲水性的均匀超顺磁性Fe3O4/聚（甲基丙烯酸甲酯-丙烯酸）（P（MMA-AA））复合纳米粒子。将铁磁流体、MMA和AA单体、表面活性剂和引发剂的混合物进行共超声处理并乳化，以制备用于聚合的稳定微乳液。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、傅里叶变换红外光谱（FT-IR）、X射线衍射（XRD）、热重分析（TGA）和振动样品磁强计（VSM）对所制备的产物进行了表征。SEM结果表明，Fe3O4/P（MMA-AA）复合纳米粒子的形态均呈近似球形，直径分别约为60nm、60nm和100nm，分别对应于Fe3O4与MMA和AA的重量比为1:8、1:4和1:2。TEM图像表明，Fe3O4/P（MMA-AA）复合纳米粒子呈现出完美的核壳结构，聚合物壳层厚度约为2nm，核心包裹着均匀且紧密堆积的Fe3O4纳米粒子。TGA和VSM表明，Fe3O4/P（MMA-AA）复合纳米粒子的最大饱和磁化强度高达45emu g(-1)，对应磁铁矿含量为78%，表现出超顺磁性。亲水性修饰和高饱和磁化强度赋予了所合成的复合纳米粒子在生物医学应用方面的广阔前景。
