Araki Hisazumi, Ono Shinya, Nishizawa Yuka, Deji Naoko, Nakazawa Jun, Morita Yoshikata, Kume Shinji, Chin-Kanasaki Masami, Isshiki Keiji, Araki Shin-ichi, Arimura Tetsuro, Maegawa Hiroshi, Uzu Takashi
Department of Medicine, Shiga University of Medical Science, Japan.
Intern Med. 2015;54(17):2213-7. doi: 10.2169/internalmedicine.54.4631. Epub 2015 Sep 1.
We report a case involving a 43-year-old Japanese woman with steroid-resistant focal segmental glomerular sclerosis (FSGS) and severe renal dysfunction, which was ameliorated by low-density lipoprotein apheresis (LDL-A). She had been treated with steroid therapy, but had experienced anuria for over 10 weeks and required hemodialysis. She was then treated with LDL-A, which resulted in improved urinary protein excretion and renal function. Her renal function recovered after 97 days of hemodialysis therapy. This case suggests that LDL-A may represent an effective rescue treatment in patients with FSGS and long-term anuria.
我们报告了一例病例，患者为一名43岁的日本女性，患有类固醇抵抗性局灶节段性肾小球硬化（FSGS）且肾功能严重受损，经低密度脂蛋白单采术（LDL-A）治疗后病情得到改善。她此前接受过类固醇治疗，但出现了超过10周的无尿症状，需要进行血液透析。随后她接受了LDL-A治疗，结果尿蛋白排泄和肾功能均有所改善。经过97天的血液透析治疗后，她的肾功能恢复。该病例表明，LDL-A可能是FSGS和长期无尿患者的一种有效挽救治疗方法。
