血管紧张素受体阻滞剂氯沙坦抑制离体人输尿管的自发运动。

Angiotensin Receptor Blocker Losartan Inhibits Spontaneous Motility of Isolated Human Ureter.

作者信息

Jankovic Slobodan M, Stojadinovic Dobrivoje, Stojadinovic Miroslav, Jankovic Snezana V, Djuric Janko M, Stojic Isidora, Kostic Marina

机构信息

Faculty of Medical Sciences, University of Kragujevac, and Clinical Center, ul. Svetozara Markovica 69, 34000, Kragujevac, Serbia.

出版信息

Eur J Drug Metab Pharmacokinet. 2016 Dec;41(6):835-838. doi: 10.1007/s13318-015-0298-x.

DOI:10.1007/s13318-015-0298-x

PMID:26328808

Abstract

BACKGROUND AND OBJECTIVES

Ureteral motility is essential for elimination of intraluminal stones, and it may be adversely affected by cardiovascular drugs that a patient is taking chronically. The aim of our study was to test whether ACE inhibitors and an angiotensin receptor blocker may influence spontaneous contractions of isolated human ureter.

METHODS

Both phasic and tonic contractions of the isolated ureteral segments taken from 10 patients were measured as changes of the longitudinal tension or pressure recordings. Captopril, enalapril and losartan were separately added to the organ baths cumulatively.

RESULTS

While enalapril (2.7 × 10-3.9 × 10 M) and captopril (6.1 × 10-2.7 × 10 M) did not affect either spontaneous activity or tone of isolated ureteral segments, losartan (2.9 × 10-4.2 × 10 M) caused concentration-dependent inhibition of spontaneous contractions of the segments (50 % effective concentration (EC) = 13.46 ± 1.80 × 10 M; F = 10.72, r = 0.79, p < 0.001).

CONCLUSIONS

Due to differences in molecular mechanism of action, angiotensin receptor blocker losartan does and ACE inhibitors captopril and enalapril do not inhibit spontaneous contractions of isolated human ureter.

摘要

背景与目的

输尿管蠕动对于管腔内结石的排出至关重要，而患者长期服用的心血管药物可能会对其产生不利影响。本研究的目的是测试血管紧张素转换酶抑制剂（ACE抑制剂）和血管紧张素受体阻滞剂是否会影响离体人输尿管的自发收缩。

方法

测量从10名患者获取的离体输尿管段的相性收缩和张力性收缩，以纵向张力或压力记录的变化作为指标。将卡托普利、依那普利和氯沙坦分别累积添加到器官浴槽中。

结果

依那普利（2.7×10⁻³.⁹×10⁻³M）和卡托普利（6.1×10⁻².⁷×10⁻²M）对离体输尿管段的自发活动或张力均无影响，而氯沙坦（2.9×10⁻⁴.²×10⁻⁴M）引起该段输尿管自发收缩的浓度依赖性抑制（半数有效浓度（EC₅₀）=13.46±1.80×10⁻⁴M；F=10.72，r=0.79，p<0.001）。