急性冷暴露对味精诱导肥胖小鼠棕色脂肪组织中去甲肾上腺素周转率、产热及代谢率的影响。

Effect of acute cold-exposure on norepinephrine turnover and thermogenesis in brown adipose tissue and metabolic rate in MSG-induced obese mice.

作者信息

Yoshioka K, Yoshida T, Kondo M

机构信息

First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.

出版信息

Jpn J Physiol. 1989;39(6):957-62. doi: 10.2170/jjphysiol.39.957.

DOI:10.2170/jjphysiol.39.957

PMID:2632905

Abstract

Mice treated neonatally with monosodium-L-glutamate (MSG) are known to develop into obese adults without hyperphagia, which are characterized by the reduced levels in the resting metabolic rate (RMR) and the thermogenesis of brown adipose tissue (BAT) in the thermoneutral environment. The present study revealed that an acute cold-exposure (5 degrees C, 1 h) of these animals resulted in the increase in norepinephrine turnover and mitochondrial-5'-diphosphate (GDP) binding in the interscapular BAT as well as the guanosine RMR, suggesting a normal thermogenic responsiveness of BAT to cold.

摘要

已知新生期用L-谷氨酸单钠（MSG）处理的小鼠会发育成肥胖的成年鼠，但无食欲亢进，其特征是在热中性环境中静息代谢率（RMR）和棕色脂肪组织（BAT）产热水平降低。本研究表明，对这些动物进行急性冷暴露（5摄氏度，1小时）会导致肩胛间BAT中去甲肾上腺素周转率和线粒体5'-二磷酸（GDP）结合增加，以及鸟苷RMR增加，这表明BAT对寒冷具有正常的产热反应。