阿片类药物、催乳素与多巴胺受体。
Opiates, prolactin, and the dopamine receptor.
作者信息
Tolis G, Dent R, Guyda H
出版信息
J Clin Endocrinol Metab. 1978 Jul;47(1):200-3. doi: 10.1210/jcem-47-1-200.
PMID:263291
Abstract
The administration of a dopamine antagonist, chlorpromazine, and two opiates, morphine and methadone, resulted in a significant rise in serum PRL within 90-150 min. Prior administration of dopamine receptor agonists (apomorphine, levodopa, aand bromocriptine) blocked this effect. In contrast, cyproheptadine, a serotonin antagonist, did not. We suggest that the opiates induce hyperprolactinemia in man via dopamine receptor blockade.
摘要
给予多巴胺拮抗剂氯丙嗪以及两种阿片类药物吗啡和美沙酮后，血清催乳素（PRL）在90 - 150分钟内显著升高。预先给予多巴胺受体激动剂（阿扑吗啡、左旋多巴和溴隐亭）可阻断这种效应。相比之下，5-羟色胺拮抗剂赛庚啶则无此作用。我们认为阿片类药物通过阻断多巴胺受体诱导人体高催乳素血症。
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