一例罕见的小唾液腺多形性腺瘤恶变黏液表皮样癌：组织病理学和免疫组织化学分析
A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis.
作者信息
Daltoe Felipe Perozzo, Grando Liliane Janete, Meurer Maria Inês, Rivero Elena Riet Correa, Modolo Filipe
机构信息
PhD Student, Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Santa Catarina, University Campus, Trindade CEP: 88040-900, Florianopolis, SC, Brazil, Phone: +55 (48) 3721-3483, e-mail:
Department of Pathology, Health Sciences Center, Federal University of Santa Catarina, Santa Catarina, Brazil.
出版信息
J Contemp Dent Pract. 2015 Jul 1;16(7):603-6. doi: 10.5005/jp-journals-10024-1728.
Mucoepidermoid carcinoma ex pleomorphic adenoma (MCxPA) is a rare salivary gland tumor predominantly found in major salivary glands. A case of MCxPA involving the soft tissue and bone of the retromolar region of a 26-year-old man is presented. The histopathological features revealed a neoplasm with predominance of pleomorphic adenoma (PA) elements, and presence of mucoepidermoid carcinoma malignant epithelial cells in several areas. Histochemical and immunohistochemical studies were positive for periodic acid Schiff, alcian blue, cytokeratins 7, 13, 14, and 19, Bcl-2, c-erbB-2, FGF-2 and maspin in the malignant areas. The patient underwent a partial resection of the left side of the mandible with neck dissection and MCxPA diagnosis was confirmed.
多形性腺瘤恶变黏液表皮样癌（MCxPA）是一种罕见的涎腺肿瘤，主要发生于大涎腺。本文报告1例26岁男性患者，其肿瘤累及磨牙后区的软组织和骨组织，病理诊断为多形性腺瘤恶变黏液表皮样癌。组织病理学特征显示肿瘤以多形性腺瘤（PA）成分占主导，同时在多个区域存在黏液表皮样癌的恶性上皮细胞。恶性区域的组织化学和免疫组织化学研究显示，过碘酸希夫反应、阿尔辛蓝染色、细胞角蛋白7、13、14和19、Bcl-2、c-erbB-2、FGF-2和maspin均呈阳性。患者接受了左侧下颌骨部分切除及颈部清扫术，术后病理确诊为多形性腺瘤恶变黏液表皮样癌。
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