Behm Barbara, Kemper Michael, Babilas Philipp, Abels Christoph, Schreml Stephan
Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.
Skin Pharmacol Physiol. 2015;28(6):290-5. doi: 10.1159/000439030. Epub 2015 Sep 1.
The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal or increased skin pH. A pH 4 W/O emulsion was applied on three areas with pathologically increased skin surface pH in diabetics (n = 10). Further, a 28-day half-side trial (n = 30) was performed to test the long-term efficacy and safety of a pH 4 W/O emulsion (n = 30). In summary, the application of a pH 4 W/O emulsion reduced the skin pH in healthy, elderly and diabetic subjects, which may improve epidermal barrier functions.
皮肤pH值对于皮肤的生理功能至关重要。在衰老或患病皮肤中观察到的角质层酸度下降可能会对皮肤的生理功能产生负面影响。因此，研究了pH值调至4的含乙醇酸的油包水（W/O）乳液对正常或升高的皮肤pH值的影响。将pH值为4的W/O乳液应用于糖尿病患者皮肤表面pH值病理性升高的三个部位（n = 10）。此外，还进行了一项为期28天的半侧试验（n = 30），以测试pH值为4的W/O乳液（n = 30）的长期疗效和安全性。总之，pH值为4的W/O乳液的应用降低了健康、老年和糖尿病受试者的皮肤pH值，这可能会改善表皮屏障功能。
