一名10岁女童的甲状旁腺癌

Parathyroid Carcinoma in a 10 Years Old Female Child.

作者信息

Rahman M M, Karim S S, Joarder A I, Mubin S, Abir M M, Morshed M S

机构信息

Dr Mohammed Mostafizur Rahman, Associate Professor, Department of Endocrine Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh; E-mail:

出版信息

Mymensingh Med J. 2015 Jul;24(3):619-23.

PMID:26329966

Abstract

Parathyroid carcinoma (PC) is a rare cause of hypercalcaemia in children. Only 7 cases of PC have been reported so far in the world journal. The authors report the 8th case of parathyroid carcinoma in children less than 16 years of age. A 10 year old girl presented with difficulty in walking, dorsiflexion and ulnar deviation of both wrist joints and occasional pain in the central abdomen of about two years duration. Biochemical investigations revealed serum calcium 12.2 mg/dL (normal 9-11 mg/dL), serum alkaline phosphate 4992 U/L (normal 50-136 U/L), PTH (parathyroid hormone) 2217 pg/ml (normal 9-80 pg/ml). Parathyroid scintigraphy localized the lesion in the left parathyroid gland. X-ray showed bilateral coxa vera, genu valgus deformity and multiple stress fractures in both wrist joints. Histopathology confirmed PC with capsular and vascular invasion.

摘要

甲状旁腺癌（PC）是儿童高钙血症的罕见病因。迄今为止，世界范围内的期刊仅报道过7例儿童甲状旁腺癌。本文作者报告了第8例16岁以下儿童甲状旁腺癌病例。一名10岁女孩出现行走困难、双腕关节背屈和尺侧偏斜，且中腹部偶尔疼痛，症状持续约两年。生化检查显示血清钙12.2mg/dL（正常范围9 - 11mg/dL），血清碱性磷酸酶4992U/L（正常范围50 - 136U/L），甲状旁腺激素（PTH）2217pg/ml（正常范围9 - 80pg/ml）。甲状旁腺闪烁扫描将病变定位于左侧甲状旁腺。X线显示双侧髋外翻、膝外翻畸形以及双腕关节多发应力性骨折。组织病理学证实为甲状旁腺癌，伴有包膜和血管侵犯。