De Bonis Michele, Lapenna Elisabetta, Pozzoli Alberto, Nisi Teodora, Giacomini Andrea, Calabrese Mariachiara, La Canna Giovanni, Pappalardo Federico, Miceli Antonio, Glauber Mattia, Barili Fabio, Alfieri Ottavio
Department of Cardiac Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Department of Cardiac Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Ann Thorac Surg. 2015 Dec;100(6):2206-12. doi: 10.1016/j.athoracsur.2015.05.108. Epub 2015 Aug 29.
The objective of this study was to assess the fate at long term of mild-to-moderate functional tricuspid regurgitation (TR) left untreated at the time of mitral valve repair in patients with dilated cardiomyopathy.
We selected from our prospective hospital database 84 patients (age, 64 ± 9.6 years; ejection fraction, 0.31 ± 0.064) who underwent mitral repair for secondary mitral regurgitation in whom concomitant mild-to-moderate TR (nonlinear scale 1 to 4+) was left untreated. Tricuspid regurgitation was classified as mild in 61 patients (72.6%) and moderate in 23 patients (27.3%). Annular dilatation itself was not systematically measured and was not used as a trigger for tricuspid annuloplasty. Most of the patients were in New York Heart Association functional class III or IV (56 of 84; 66.7%).
At a median follow-up of 7.3 years (interquartile range, 4.5 to 9.3), 17 patients (20.2%) had moderate-to-severe TR and 21 patients (25%) showed a progression of at least two grades of their untreated preoperative TR. Freedom from moderate-to-severe TR or from progression of at least two grades of the baseline TR was 77% ± 5% at 5 years and 56.7% ± 8.4% at 10 years. Multivariate analysis identified preoperative right ventricular dysfunction (hazard ratio, 7.2; 95% confidence interval, 2.8 to 23; p = 0.001) and age (hazard ratio, 1; 95% confidence interval, 1.0 1.1; p = 0.03) as independent predictors of TR worsening.
A significant number of dilated cardiomyopathy patients with mild-to-moderate TR left untreated at the time of mitral repair show important TR at follow-up. In this setting, a more aggressive policy should be used taking into consideration the degree of annular dilatation and the function of the right ventricle and not simply the grade of TR.
本研究的目的是评估扩张型心肌病患者二尖瓣修复时未治疗的轻至中度功能性三尖瓣反流(TR)的长期转归。
我们从前瞻性医院数据库中选取了84例患者(年龄64±9.6岁;射血分数0.31±0.064),这些患者因继发性二尖瓣反流接受二尖瓣修复,同时伴有轻至中度TR(非线性分级1至4+)未治疗。61例患者(72.6%)的三尖瓣反流为轻度,23例患者(27.3%)为中度。未系统测量瓣环扩张情况,且未将其作为三尖瓣环成形术的触发因素。大多数患者处于纽约心脏协会心功能Ⅲ或Ⅳ级(84例中的56例;66.7%)。
中位随访7.3年(四分位间距4.5至9.3年)时,17例患者(20.2%)出现中至重度TR,21例患者(25%)术前未治疗的TR至少进展了两级。5年时无中至重度TR或基线TR至少进展两级的患者比例为77%±5%,10年时为56.7%±8.4%。多因素分析确定术前右心室功能障碍(风险比7.2;95%置信区间2.8至23;p = 0.001)和年龄(风险比1;95%置信区间1.0至1.1;p = 0.03)是TR恶化的独立预测因素。
大量二尖瓣修复时未治疗轻至中度TR的扩张型心肌病患者在随访时出现明显的TR。在此情况下,应采用更积极的策略,考虑瓣环扩张程度和右心室功能,而不仅仅是TR的分级。