Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China.
State Key Laboratory of Southern China, The Chinese University of Hong Kong, Sir Y.K. Pau Cancer Center, Prince of Wales Hospital, Hong Kong, China.
Cancer. 2015 Sep 1;121 Suppl 17:3089-96. doi: 10.1002/cncr.29522.
Since the discovery of epidermal growth factor receptor mutations and epidermal growth factor receptor tyrosine kinase inhibitors, lung cancer treatment in China has entered the precision era. However, novel targeted agents based on novel biomarkers still need to be developed. In the current study, the authors review the biomarker features of lung cancer in the Chinese population and the novel agents that are aimed at novel targets. Furthermore, they discuss issues that require improvement for the production of novel drugs and provided future directions for development in China.
自发现表皮生长因子受体突变和表皮生长因子受体酪氨酸激酶抑制剂以来,中国的肺癌治疗已进入精准时代。然而,仍需要开发基于新型生物标志物的新型靶向药物。在目前的研究中,作者综述了中国人群肺癌的生物标志物特征以及针对新型靶点的新型药物。此外,他们还讨论了新药研发需要改进的问题,并为中国的未来发展方向提供了建议。