Frasier S D, Aceto T, Hayles A B
J Clin Endocrinol Metab. 1978 Sep;47(3):686-8. doi: 10.1210/jcem-47-3-686.
Twenty-two GH-deficient patients received 6 IU GH weekly for 6 months. They increased their growth rate from 1.0 +/- 0.2 to 2.9 +/- 0.3 (SE) cm/6 months (P less than 0.01). However, their rate of growth was significantly less (P less than 0.05) than the rate [4.1 +/- 0.5 (SE) cm/6 months] observed earlier when they had received 2 IU GH three times a week. Seven patients received weekly GH for 18 months and they also grew significantly less (P less than 0.01) than when they had received GH divided over the week. These results suggest that once a week GH does not provide the most effective therapy for GH deficiency.
22名生长激素缺乏患者每周接受6国际单位生长激素治疗，为期6个月。他们的生长速率从1.0±0.2增加到2.9±0.3（标准误）厘米/6个月（P<0.01）。然而，他们的生长速率显著低于（P<0.05）早期接受每周三次、每次2国际单位生长激素治疗时观察到的速率[4.1±0.5（标准误）厘米/6个月]。7名患者接受每周一次生长激素治疗18个月，他们的生长也显著低于接受每周分次注射生长激素时的情况（P<0.01）。这些结果表明，每周一次的生长激素治疗并非生长激素缺乏最有效的治疗方法。
