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[免疫过敏性呼吸道疾病患者淋巴细胞群体及亚群的测定]

[Determination of lymphocyte populations and subpopulations in patients with immunoallergic respiratory disease].

作者信息

Revigliono M, González de Niro G, de Barayazarra S, Faillaci M G

出版信息

Rev Alerg Mex (1987). 1989 Nov-Dec;36(6):235-40.

PMID:2633307
Abstract

The serum IgE levels were determined; LB and LT groups and T4 (CD4+) and T8 (CD8+) subgroups were quantified, in 20 patients with immunoallergic respiratory disease (rhinosinusitis and/or bronchial asthma). The IgE levels were raised in 90% of the patients (mean value 412 IU/ml; range 56-1000 IU/ml). The LB count was normal or reduced. There was a relationship between LT count and IgE: for low levels of IgE, the LT count was normal and below normal when the IgE levels were high. The T8 subgroup count was normal in 50% of the patients. The T4 subgroup count was below normal in 80% of the patients. Perhaps, a more detailed study of T4 subgroup components, would explain the immunologic finding in these patients. We can conclude that the immune system must be thoroughly studied before instituting a specific immunotherapy.

摘要

对20例免疫过敏性呼吸道疾病(鼻窦炎和/或支气管哮喘)患者测定了血清IgE水平;对LB和LT组以及T4(CD4 +)和T8(CD8 +)亚组进行了定量分析。90%的患者IgE水平升高(平均值412 IU/ml;范围56 - 1000 IU/ml)。LB计数正常或降低。LT计数与IgE之间存在关联:IgE水平低时,LT计数正常;IgE水平高时,LT计数低于正常。50%的患者T8亚组计数正常。80%的患者T4亚组计数低于正常。或许,对T4亚组成分进行更详细的研究,将解释这些患者的免疫学发现。我们可以得出结论,在开展特异性免疫治疗之前,必须对免疫系统进行全面研究。

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