Vaira F, Nazzaro G, Pesapane F, Brambilla L, Coggi A, Fanoni D, Venegoni L, Tourlaki A, Gianotti R, Berti E
Department of Medical and Surgical Physiopathology and of Transplants University of Milan, Unit of Dermatology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy -
G Ital Dermatol Venereol. 2015 Oct;150(5):617-21.
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin, arising from pluripotent precursors of Merkel cells. The tumor most frequently affects head and neck of elderly patients. It increases with sun exposure and after immunosuppression and organ transplantation. Because of a possible viral association, interest in MCC has escalated. A new polyomavirus, Merkel cell polyomavirus (MCPyV), was identified and associated to MCC. In support of this hypothesis, we report three new clinical cases of MCC in which we detected MCPyV by immunohistochemistry and provide an update on current thinking about the MCC.
默克尔细胞癌（MCC）是一种具有高度侵袭性的皮肤神经内分泌癌，起源于默克尔细胞的多能前体细胞。该肿瘤最常累及老年患者的头颈部。其发病率随日晒以及免疫抑制和器官移植后而增加。由于可能与病毒有关联，对MCC的关注度不断提高。一种新的多瘤病毒，默克尔细胞多瘤病毒（MCPyV），已被鉴定并与MCC相关联。为支持这一假说，我们报告了3例新的MCC临床病例，我们通过免疫组织化学检测到了MCPyV，并提供了关于MCC当前认识的最新情况。
