Arcizet Fabrice, Mirpour Koorosh, Foster Daniel J, Charpentier Caroline J, Bisley James W
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California;
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California; Ecole Normale Superieure (ENS), Lyon, France;
J Neurophysiol. 2015 Nov;114(5):2637-48. doi: 10.1152/jn.00604.2015. Epub 2015 Sep 2.
When looking around at the world, we can only attend to a limited number of locations. The lateral intraparietal area (LIP) is thought to play a role in guiding both covert attention and eye movements. In this study, we tested the involvement of LIP in both mechanisms with a change detection task. In the task, animals had to indicate whether an element changed during a blank in the trial by making a saccade to it. If no element changed, they had to maintain fixation. We examine how the animal's behavior is biased based on LIP activity prior to the presentation of the stimulus the animal must respond to. When the activity was high, the animal was more likely to make an eye movement toward the stimulus, even if there was no change; when the activity was low, the animal either had a slower reaction time or maintained fixation, even if a change occurred. We conclude that LIP activity is involved in both covert and overt attention, but when decisions about eye movements are to be made, this role takes precedence over guiding covert attention.
环顾世界时，我们只能关注有限数量的位置。顶内沟外侧区（LIP）被认为在引导隐蔽注意力和眼球运动中都发挥作用。在本研究中，我们通过一个变化检测任务来测试LIP在这两种机制中的参与情况。在该任务中，动物必须通过向某个元素扫视来表明在试验中的空白期间该元素是否发生了变化。如果没有元素发生变化，它们必须保持注视。我们研究了在动物必须做出反应的刺激呈现之前，基于LIP活动，动物的行为是如何产生偏差的。当活动水平较高时，即使没有变化，动物也更有可能朝刺激物进行眼球运动；当活动水平较低时，即使发生了变化，动物要么反应时间较慢，要么保持注视。我们得出结论，LIP活动参与了隐蔽和显性注意力，但在要做出关于眼球运动的决策时，这一作用优先于引导隐蔽注意力。
