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Single nucleotide polymorphisms for genes encoding cytokines in the context of cardiac surgery. Part I: Heart transplantation.心脏手术中细胞因子编码基因的单核苷酸多态性。第一部分：心脏移植。
Kardiochir Torakochirurgia Pol. 2015 Mar;12(1):48-52. doi: 10.5114/kitp.2015.50568. Epub 2015 Mar 31.
2
Cytokine gene polymorphisms in kidney transplantation.肾移植中的细胞因子基因多态性
Transplant Proc. 2013 Jul-Aug;45(6):2152-7. doi: 10.1016/j.transproceed.2012.12.006. Epub 2013 Jun 6.
3
Cytokine gene polymorphisms and acute human liver graft rejection.细胞因子基因多态性与人类肝脏移植急性排斥反应
Liver Transpl. 2002 Jul;8(7):603-11. doi: 10.1053/jlts.2002.33967.
4
Cytokine single nucleotide polymorphisms and intrarenal gene expression in chronic allograft nephropathy in children.儿童慢性移植肾肾病中细胞因子单核苷酸多态性与肾内基因表达
Kidney Int. 2003 Jul;64(1):314-20. doi: 10.1046/j.1523-1755.2003.00050.x.
5
Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients.白细胞介素-2、白细胞介素-10、转化生长因子-β1和白细胞介素-2受体β链的基因多态性与肾移植患者的急性排斥反应
Clin Transplant. 2014 Jun;28(6):649-55. doi: 10.1111/ctr.12346. Epub 2014 Jun 3.
6
Risk of adverse post-transplant events after kidney allograft transplantation as predicted by CTLA-4 +49 and TNF-alpha -308 single nucleotide polymorphisms: a preliminary study.CTLA-4 +49和TNF-α -308单核苷酸多态性预测肾移植术后不良事件的风险：一项初步研究。
Transpl Immunol. 2006 Nov;16(3-4):194-9. doi: 10.1016/j.trim.2006.09.001. Epub 2006 Sep 26.
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8
Study of the cytokine polymorphisms in correlation to rejection and graft survival in renal allograft donors and recipients from a homogenous Saudi population.研究同种沙特人群肾移植供受者细胞因子多态性与排斥和移植物存活的关系。
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9
Analysis of cytokine gene polymorphisms in recipient's matched with living donors on acute rejection after renal transplantation.肾移植后与活体供者配型的受者中细胞因子基因多态性与急性排斥反应的分析。
Mol Cell Biochem. 2008 Apr;311(1-2):57-65. doi: 10.1007/s11010-007-9694-0. Epub 2007 Dec 29.
10
Cytokine Gene Polymorphism Profiles in Kidney Transplant Patients - Association of +1188A/C RS3212227 SNP in the IL12B Gene Prevents Delayed Graft Function.肾移植患者细胞因子基因多态性分析-白细胞介素 12B 基因+1188A/C RS3212227 单核苷酸多态性与延迟移植物功能有关。
Arch Med Res. 2018 Feb;49(2):101-108. doi: 10.1016/j.arcmed.2018.04.015. Epub 2018 May 10.

本文引用的文献

1
Meta-analysis of cytokine gene polymorphisms and outcome of heart transplantation.细胞因子基因多态性与心脏移植结局的荟萃分析。
Biomed Res Int. 2013;2013:387184. doi: 10.1155/2013/387184. Epub 2013 Aug 20.
2
The association between cytokine gene polymorphisms and graft rejection in liver transplantation: a systematic review and meta-analysis.细胞因子基因多态性与肝移植中移植物排斥反应的关系：系统评价和荟萃分析。
Transpl Immunol. 2013 Jan;28(1):62-70. doi: 10.1016/j.trim.2012.10.003. Epub 2012 Oct 24.
3
Scientific Registry of the International Society for Heart and Lung Transplantation: introduction to the 2009 Annual Reports.国际心肺移植学会科学注册处：2009年年度报告介绍。
J Heart Lung Transplant. 2009 Oct;28(10):989-92. doi: 10.1016/j.healun.2009.08.005.
4
No association between single nucleotide polymorphisms and the development of nephrotoxicity after orthotopic heart transplantation.单核苷酸多态性与原位心脏移植后肾毒性的发生之间无关联。
J Heart Lung Transplant. 2008 Jul;27(7):741-5. doi: 10.1016/j.healun.2008.04.001. Epub 2008 May 23.
5
Association between cytokine gene polymorphisms and outcomes in renal transplantation: a meta-analysis of individual patient data.细胞因子基因多态性与肾移植结局之间的关联：个体患者数据的荟萃分析
Nephrol Dial Transplant. 2008 Sep;23(9):3017-23. doi: 10.1093/ndt/gfn185. Epub 2008 Apr 11.
6
Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients.儿科心脏移植患者不同种族和族裔群体中16个候选单核苷酸多态性的分布差异。
Transplantation. 2006 Dec 27;82(12):1774-80. doi: 10.1097/01.tp.0000250656.33731.08.
7
Genetic polymorphism in platelet-derived growth factor and vascular endothelial growth factor are significantly associated with cardiac allograft vasculopathy.血小板衍生生长因子和血管内皮生长因子的基因多态性与心脏移植血管病变显著相关。
J Heart Lung Transplant. 2006 Jun;25(6):690-8. doi: 10.1016/j.healun.2006.02.006.
8
Interleukin-6 polymorphism: a genetic risk factor for cardiac transplant related coronary vasculopathy?
J Heart Lung Transplant. 2005 May;24(5):559-65. doi: 10.1016/j.healun.2004.03.016.
9
Tumor necrosis factor gene polymorphism and cardiac allograft vasculopathy.肿瘤坏死因子基因多态性与心脏移植血管病变
J Heart Lung Transplant. 2005 Apr;24(4):433-8. doi: 10.1016/j.healun.2004.02.019.
10
Donor and recipient-transforming growth factor-beta 1 polymorphism and cardiac transplant-related coronary artery disease.供体和受体转化生长因子-β1多态性与心脏移植相关冠状动脉疾病
Transpl Immunol. 2004 Nov;13(3):211-7. doi: 10.1016/j.trim.2004.06.005.

心脏手术中细胞因子编码基因的单核苷酸多态性。第一部分：心脏移植。

Single nucleotide polymorphisms for genes encoding cytokines in the context of cardiac surgery. Part I: Heart transplantation.

作者信息

Danikiewicz Aleksander, Szkodzinski Janusz, Hudzik Bartosz, Korzonek-Szlacheta Ilona, Gąsior Mariusz, Polonski Lech, Zubelewicz-Szkodzińska Barbara

机构信息

Department for the Prevention of Food-related Diseases, School of Public Health, Medical University of Silesia, Katowice, Poland.

Third Chair and Department of Cardiology, Medical University of Silesia in Katowice, School of Medicine with the Division of Dentistry in Zabrze, Silesian Center for Heart Diseases in Zabrze, Poland.

出版信息

Kardiochir Torakochirurgia Pol. 2015 Mar;12(1):48-52. doi: 10.5114/kitp.2015.50568. Epub 2015 Mar 31.

DOI:10.5114/kitp.2015.50568
PMID:26336478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4520503/
Abstract

Cardiovascular diseases remain the leading cause of death in Poland and other countries of the European Union. Patients with end-stage heart failure constitute a patient subgroup for whom the treatment of choice is heart transplantation. Despite advances in immunosuppressive therapy, acute or chronic graft rejection occurs in 20-30% of cases in the first six months after transplantation. The significance of the immune response and inflammation in graft rejection implies the important role of cytokines. Molecular markers are sought to facilitate risk assessment and improve patient care. At present, genetic tests are not used for this purpose, but studies aiming to rectify that have been conducted for years, including studies on single nucleotide polymorphisms of cytokine genes. This paper presents the results of research on the single nucleotide polymorphisms (SNPs) of the IL-2, IL-4, IL-6, IL-10, TGF-β1, PDGF, VEGF, and TNF-α genes in conjunction with heart transplantation. The analyzed data do not allow for reliable application of these genetic tests in clinical practice, but suggest that it is a promising direction which may improve the options of treatment individualization in the future.

摘要

心血管疾病仍然是波兰和其他欧盟国家的主要死因。终末期心力衰竭患者构成了一个患者亚组，对于他们来说，首选治疗方法是心脏移植。尽管免疫抑制治疗取得了进展，但在移植后的头六个月内，20%-30%的病例会发生急性或慢性移植物排斥反应。免疫反应和炎症在移植物排斥反应中的重要性意味着细胞因子起着重要作用。人们一直在寻找分子标志物以促进风险评估并改善患者护理。目前，基因检测尚未用于此目的，但多年来一直在进行旨在纠正这一情况的研究，包括对细胞因子基因单核苷酸多态性的研究。本文介绍了与心脏移植相关的白细胞介素-2（IL-2）、白细胞介素-4（IL-4）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、转化生长因子-β1（TGF-β1）、血小板衍生生长因子（PDGF）、血管内皮生长因子（VEGF）和肿瘤坏死因子-α（TNF-α）基因单核苷酸多态性（SNP）的研究结果。分析的数据不允许在临床实践中可靠地应用这些基因检测，但表明这是一个有前景的方向，未来可能会改善治疗个体化的选择。