Yoshifuku Kousuke, Nishimoto Kengo, Matsuzaki Tsutomu, Ushikai Masato
Nihon Jibiinkoka Gakkai Kaiho. 2015 Jun;118(6):776-81. doi: 10.3950/jibiinkoka.118.776.
We report herein on a case of a 74 year old male with neurally mediated syncope caused by cervical malignant lymphoma. He visited our hospital complaining of a rapidly-growing left cervical mass. Local findings showed an elastic soft mass with tenderness in his cervical region. We performed an open biopsy and pathological diagnosis was diffuse large B-cell lymphoma, so we planned to treat him with CHOP therapy. But before chemotherapy, loss of consciousness occurred. This syncope was considered to be neurally mediated syncope caused by the compression of the carotid sinus by the cervical malignant lymphoma. His cervical malignant lymphoma rapidly shrank after CHOP therapy, and general fatigue and bradycardia decreased day by day. If cardiac pacemaker insertion is not enforced for a case of neurally mediated syncope, the frequency of the syncope increases. In this case the cervical tumor was reduced by CHOP therapy and the syncope and bradycardia disappeared. The patient was able to avoid cardiac pacemaker insertion.
我们在此报告一例74岁男性因颈部恶性淋巴瘤导致神经介导性晕厥的病例。他因左侧颈部肿块迅速增大前来我院就诊。局部检查发现其颈部有一个有弹性的柔软肿块且有压痛。我们进行了开放性活检,病理诊断为弥漫性大B细胞淋巴瘤,因此计划对他进行CHOP方案化疗。但在化疗前,患者出现了意识丧失。这种晕厥被认为是颈部恶性淋巴瘤压迫颈动脉窦导致的神经介导性晕厥。经CHOP方案化疗后,他的颈部恶性淋巴瘤迅速缩小,全身乏力和心动过缓也逐日减轻。对于神经介导性晕厥的病例,如果不强制植入心脏起搏器,晕厥的发作频率会增加。在本病例中,通过CHOP方案化疗颈部肿瘤缩小,晕厥和心动过缓消失。患者得以避免植入心脏起搏器。