Kabir Muammar M, Ghafoori Elyar, Tereshchenko Larisa G
Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA.
Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA.
J Electrocardiol. 2015 Nov-Dec;48(6):1027-31. doi: 10.1016/j.jelectrocard.2015.08.018. Epub 2015 Aug 5.
The purposes of this study were to characterize and quantify concordance between consecutive atrial and ventricular activation time points through analysis of phases and to explore its association with outcomes in patients with implantable cardioverter-defibrillator (ICD). Patients with structural heart disease and dual-chamber ICDs underwent 5min baseline right ventricular (V) near-field and atrial (A) electrogram (EGM) recording. The cross-dependencies of phase dynamics of the changes in consecutive A (AA') and V (VV') were quantified and the AV phase dependency index was determined. In Cox regression analysis, a high AV phase index (in the highest quartile, >0.259) was significantly associated with higher risk of ventricular tachyarrhythmias (HR 2.84; 95% CI 1.05-7.67; P=0.04). In conclusion, in ICD patients with structural heart disease, high sinus AV phase dependency index on EGM is associated with the risk of ventricular arrhythmia.
本研究的目的是通过相位分析来表征和量化连续心房和心室激活时间点之间的一致性，并探讨其与植入式心脏复律除颤器（ICD）患者预后的关联。患有结构性心脏病且植入双腔ICD的患者进行了5分钟的基线右心室（V）近场和心房（A）心电图（EGM）记录。对连续A（AA'）和V（VV'）变化的相位动力学的交叉依赖性进行了量化，并确定了房室相位依赖性指数。在Cox回归分析中，高房室相位指数（处于最高四分位数，>0.259）与室性快速心律失常的较高风险显著相关（HR 2.84；95%CI 1.05-7.67；P=0.04）。总之，在患有结构性心脏病的ICD患者中，EGM上高窦性房室相位依赖性指数与室性心律失常风险相关。
