Sukhareva N N, Zaretskaia M Sh, Khorokhorina V A, Egorov N S, Viadro M M, Titova T S, Fomina I P
Antibiot Khimioter. 1989 Nov;34(11):834-6.
A membrane-bound glycoprotein with a molecular weight of 10000-12000 was isolated from Crithidia oncopelti and purified. The glycoprotein contained peptide, carbohydrate and lipid fragments and phosphorus. The peptide fragment was represented by 10 amino acids. The carbohydrate fragment was represented by 7 monosaccharides. The lipid part was mainly represented by stearic acid. The glycoprotein showed immunostimulating properties. It had a comitogenic effect on murine spleen cells in vitro and induced tumoricidal activity in murine peritoneal macrophages in vitro and in vivo.
从克氏锥虫中分离并纯化出一种分子量为10000 - 12000的膜结合糖蛋白。该糖蛋白含有肽、碳水化合物、脂质片段和磷。肽片段由10种氨基酸组成。碳水化合物片段由7种单糖组成。脂质部分主要由硬脂酸组成。该糖蛋白具有免疫刺激特性。它在体外对小鼠脾细胞有协同有丝分裂作用，在体外和体内均可诱导小鼠腹腔巨噬细胞产生杀肿瘤活性。
