[瑞斯托霉素A的碳水化合物成分对人血浆中血小板聚集的影响]
[Effect of carbohydrate components of ristomycin A on platelet aggregation in human plasma].
作者信息
Trifonova Zh P, Sturman N V, Zheltova A O, Katrukha G S
出版信息
Antibiot Khimioter. 1989 Nov;34(11):846-8.
PMID:2633701
Abstract
In the process of the investigation, conditions for specific removal of arabinose in tetrasaccharide of ristomycin A, a glycopeptide antibiotic as well as conditions for simultaneous removal of arabinose and mannose-2 bound to actinoidinic acid were determined. The role of arabinose in manifestation of the ristomycin A ability to induce platelet aggregation was shown to be important. Mannose-2 also had the same ability while its level was somewhat lower.
摘要
在研究过程中，确定了从糖肽抗生素瑞斯托霉素A四糖中特异性去除阿拉伯糖的条件，以及同时去除与放线菌素酸结合的阿拉伯糖和甘露糖-2的条件。结果表明，阿拉伯糖在瑞斯托霉素A诱导血小板聚集能力的表现中起着重要作用。甘露糖-2也具有相同的能力，但其水平略低。
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