Noda Yoshifumi, Goshima Satoshi, Kanematsu Masayuki, Watanabe Haruo, Kawada Hiroshi, Kawai Nobuyuki, Ono Hiromi, Bae Kyongtae T
Departments of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.
Departments of Radiology Services, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.
Ann Nucl Med. 2016 Jan;30(1):11-7. doi: 10.1007/s12149-015-1023-1. Epub 2015 Sep 4.
To evaluate the contributory value of Fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in the prediction of lymphovascular tumor invasion in patients with lung adenocarcinoma.
We evaluated F-18 FDG-PET/CT images in 84 patients with histopathologically proven lung adenocarcinoma (37 men and 47 women, age range 39-83 years, mean age 67.0 ± 8.9 years). The maximum standardized uptake values (SUVmax) of the carcinomas were measured from the PET images. The Mann-Whitney U test was conducted to compare the median SUVmax between the tumor groups with and without lymphovascular invasion. In the subgroup patients with no lymph-node metastasis, we also compared the median SUVmax between the tumor groups with and without lymphatic invasion.
The tumors with lymphovascular invasion had a significantly (P < 0.0001) greater median SUVmax than those without invasion. In the subgroup patients with no lymph-node metastasis, the median SUVmax was higher in tumors with lymphatic invasion than those without (P = 0.0004). The sensitivity, specificity, and area under the receiver operating characteristic curve for the detection of tumors with lymphovascular invasion were 89, 75 %, and 0.82, respectively, with a cutoff SUVmax value of 2.32.
The SUVmax of lung adenocarcinoma is a potential imaging biomarker for predicting tumor lymphovascular invasion.
评估氟-18氟脱氧葡萄糖（F-18 FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）在预测肺腺癌患者肿瘤淋巴管侵犯中的价值。
我们评估了84例经组织病理学证实为肺腺癌患者（37例男性和47例女性，年龄范围39 - 83岁，平均年龄67.0±8.9岁）的F-18 FDG - PET/CT图像。从PET图像中测量癌灶的最大标准化摄取值（SUVmax）。采用曼-惠特尼U检验比较有和无淋巴管侵犯的肿瘤组之间的SUVmax中位数。在无淋巴结转移的亚组患者中，我们还比较了有和无淋巴管侵犯的肿瘤组之间的SUVmax中位数。
有淋巴管侵犯的肿瘤的SUVmax中位数显著高于无侵犯者（P < 0.0001）。在无淋巴结转移的亚组患者中，有淋巴管侵犯的肿瘤的SUVmax中位数高于无侵犯者（P = 0.0004）。检测有淋巴管侵犯肿瘤的灵敏度、特异度和受试者操作特征曲线下面积分别为89%、75%和0.82，SUVmax临界值为2.32。
肺腺癌的SUVmax是预测肿瘤淋巴管侵犯的潜在影像学生物标志物。
