Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 (China) http://luosz.iccas.ac.cn.
Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12645-8. doi: 10.1002/anie.201505946. Epub 2015 Sep 4.
An efficient dual catalytic system composed of a chiral primary amine and a palladium complex was developed to promote the direct asymmetric allylic alkylation (AAA) of β-ketocarbonyl compounds. In particular, the synergistic dual catalytic system enabled the AAA reaction of challenging acyclic aliphatic ketones, such as β-ketocarbonyl compounds and 1,3-diketones.
开发了一种由手性伯胺和钯配合物组成的高效双催化体系，以促进β-酮羰基化合物的直接不对称烯丙基烷基化反应（AAA）。特别是，协同双催化体系能够实现具有挑战性的无环脂肪族酮（如β-酮羰基化合物和 1,3-二酮）的 AAA 反应。
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