用异吲哚酮、磺酰胺、酰亚胺、胺和 - 杂环进行催化不对称烯丙基胺化反应
Catalytic Asymmetric Allylic Amination with Isatins, Sulfonamides, Imides, Amines, and -Heterocycles.
作者信息
Lynch Ciarán C, Balaraman Kaluvu, Wolf Christian
机构信息
Department of Chemistry, Georgetown University, 37th and O Streets, Washington, DC 20057, United States.
出版信息
Org Lett. 2020 Apr 17;22(8):3180-3184. doi: 10.1021/acs.orglett.0c00936. Epub 2020 Apr 7.
Abstract
A generally useful palladium-catalyzed method for the asymmetric allylic amination with a large variety of isatins, sulfonamides, imides, amines, and -heterocycles is introduced. A single protocol with a readily available catalyst accomplishes this reaction at room temperature with high yields and enantioselectivities often exceeding 90%, which is demonstrated with 31 examples.
摘要
介绍了一种通用的钯催化方法，用于与多种异吲哚酮、磺酰胺、酰亚胺、胺和杂环进行不对称烯丙基胺化反应。使用一种易于获得的催化剂，通过单一方案在室温下即可完成该反应，产率高，对映选择性通常超过90%，31个实例证明了这一点。
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