Lin Meng-Han, Chang C Allen, Fischer Wolfgang B
a Institute of Biophotonics, School of Biomedical Science and Engineering, and Biophotonics & Molecular Imaging Research Center (BMIRC) , National Yang-Ming University , Taipei 112 , Taiwan.
b Department of Biomedical Imaging and Radiological Sciences , School of Biomedical Science and Engineering & Molecular Imaging Research Center (BMIRC), National Yang-Ming University , Taipei , Taiwan.
J Biomol Struct Dyn. 2016 Aug;34(8):1717-24. doi: 10.1080/07391102.2015.1090342. Epub 2015 Nov 18.
Epidermal growth factor (EGF) and homodimeric vascular endothelial growth factor (VEGF) bind to cell surface receptors. They are responsible for cell growth and angiogenesis, respectively. Docking of the individual proteins as monomeric units using ZDOCK 2.3.2 reveals a partial blocking of the receptor binding site of VEGF by EGF. The receptor binding site of EGF is not affected by VEGF. The calculated binding energy is found to be intermediate between the binding energies calculated for Alzheimer's Aß42 and the barnase/barstar complex.
表皮生长因子（EGF）和同型二聚体血管内皮生长因子（VEGF）与细胞表面受体结合。它们分别负责细胞生长和血管生成。使用ZDOCK 2.3.2将单个蛋白质作为单体单元对接，结果显示EGF会部分阻断VEGF的受体结合位点。EGF的受体结合位点不受VEGF影响。计算得出的结合能介于阿尔茨海默病Aβ42和巴纳酶/巴司塔复合物计算出的结合能之间。
