Sassard J, Barres C, Cerutti C, Julien C, Lo M, Gustin M P, Vincent M, Paultre C Z
Bull Acad Natl Med. 1989 Dec;173(9):1219-22; discussion 1223.
The consequences of a chronic destruction of sympathetic nerves or of the blockade of the renin angiotensin system (RAS) on the blood pressure (BP) level and its spontaneous variability were studied using a computerized method which allows a continuous monitoring of BP in conscious unrestrained rats. Guanethidine, used to lesion the sympathetic fibres did not alter the BP level but significantly enhanced its variability. On the opposite, angiotensin converting enzyme inhibition decreased the BP level without changing its variability. It is concluded that both systems play a complementary role as the RAS determines the long-term BP level while the sympathetic nerves control its short-term variability in conscious animals.
采用一种能对清醒自由活动大鼠的血压进行连续监测的计算机化方法，研究了交感神经的慢性破坏或肾素 - 血管紧张素系统（RAS）阻断对血压水平及其自发变异性的影响。用于损伤交感神经纤维的胍乙啶并未改变血压水平，但显著增强了其变异性。相反，血管紧张素转换酶抑制降低了血压水平，而未改变其变异性。得出的结论是，这两个系统发挥互补作用，因为RAS决定长期血压水平，而交感神经控制清醒动物的短期血压变异性。
