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[在小儿骨科手术中使用苯唑西林(必舒林)进行预防性抗生素治疗]

[Prophylactic antibiotic therapy using oxacillin (Bristopen) in pediatric orthopedic surgery].

作者信息

Bernière J, Schrayer S, Goldenberg H, Granados M, Boudet L, Scemama M P, Lassaux A

机构信息

Service Anesthésie, Hôpital Tenon-Trousseau, Paris.

出版信息

Cah Anesthesiol. 1989 Nov;37(7):507-10.

PMID:2633865
Abstract

The aim of this study was to evaluate the efficiency of oxacillin in the prophylaxis of bone infections in orthopaedic surgery in children. Staphylococcus is the usual pathogen in orthopaedics. This is the reason of our choice: oxacillin. 420 patients are included: 195 control patients did not receive any prophylactic antibiotherapy; 225 patients received oxacillin. The oxacillin treatment started at anaesthetic induction and was carried on for 72 hours. In the control group, 7 superficial and 4 deep infections were observed, while a single superficial infection was noted in the oxacillin-treated group. This easy and inexpensive prophylactic treatment gave excellent results. We think that it should be systematically administered in orthopedic surgery to ensure as little complication as possible to the child.

摘要

本研究的目的是评估苯唑西林在预防儿童骨科手术中骨感染方面的有效性。葡萄球菌是骨科常见的病原体。这就是我们选择苯唑西林的原因。共纳入420例患者:195例对照患者未接受任何预防性抗生素治疗;225例患者接受了苯唑西林治疗。苯唑西林治疗在麻醉诱导时开始,并持续72小时。在对照组中,观察到7例表浅感染和4例深部感染,而在苯唑西林治疗组中仅发现1例表浅感染。这种简便且廉价的预防性治疗取得了优异的效果。我们认为,在骨科手术中应系统性地使用该药物,以确保儿童尽可能少地出现并发症。

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