一名进行性共济失调和腭震颤患者下橄榄核的代谢亢进

Hypermetabolism of Olivary Nuclei in a Patient with Progressive Ataxia and Palatal Tremor.

作者信息

Korpela Jaana, Joutsa Juho, Rinne Juha O, Bergman Jörgen, Kaasinen Valtteri

机构信息

Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland.

Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland ; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland ; Department of Clinical Neurophysiology, Turku University Hospital and University of Turku, Turku, Finland.

出版信息

Tremor Other Hyperkinet Mov (N Y). 2015 Aug 31;5:342. doi: 10.7916/D8PV6JMT. eCollection 2015.

DOI:10.7916/D8PV6JMT

PMID:26339529

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4557084/

Abstract

BACKGROUND

The pathophysiology of the movement disorder progressive ataxia with palatal tremor (PAPT) is unclear.

CASE REPORT

A 77-year-old male presented with dysarthria, ataxia, and 1-2 Hz palatal tremor. A diagnosis of probable sporadic PAPT was established. Brain magnetic resonance imaging was normal at the presymptomatic phase but later showed olivary hypertrophy. Brain [(18)F]-fludeoxyglucose (FDG) positron emission tomography (PET) showed bilateral hypermetabolism in the olivary nuclei.

DISCUSSION

This second reported patient with PAPT and FDG-PET shows that olivary hypertrophy is paralleled with hypermetabolism. The olivary nuclei pathology also appears to be temporally associated with symptom onset.

摘要