Karadag Ayse Serap, Ozlu Emin, Akdeniz Necmettin, Uzuncakmak Tugba Kevser, Turkoglu Zafer, Ozkanli Seyma, Zemheri Ebru
a Department of Dermatology , School of Medicine, Istanbul Medeniyet University , Istanbul , Turkey .
b Department of Dermatology, Faculty of Medicine, Goztepe Research and Training Hospital , Istanbul Medeniyet University , Istanbul , Turkey .
Cutan Ocul Toxicol. 2016;35(2):157-9. doi: 10.3109/15569527.2015.1067227. Epub 2015 Jul 30.
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is a type IV hypersensitivity reaction characterized by a symmetrical erythematous rash in the gluteal and intertriginous areas. SDRIFE was previously considered to be the same presentation as Baboon Syndrome, however, has been suggested to be a different entity in the recent publications. The lesions are generally maculopapular and there is no mucosal involvement. To date, no case with petechial findings and mucosal involvement has been reported in the literature. The present study reports a SDRIFE case with a symmetrical erythematous petechial rash and oral mucosal involvement after taking oral amoxicillin.
对称性药物相关的褶烂和屈侧疹（SDRIFE）是一种IV型超敏反应，其特征为在臀部和褶烂部位出现对称性红斑疹。SDRIFE以前被认为与狒狒综合征表现相同，然而，最近的出版物表明它是一种不同的疾病实体。病变通常为斑丘疹，无黏膜受累。迄今为止，文献中尚未报道有瘀点表现和黏膜受累的病例。本研究报告了1例服用口服阿莫西林后出现对称性红斑瘀点疹和口腔黏膜受累的SDRIFE病例。
