同源寡聚体蛋白中相互关联的图景。
The Landscape of Intertwined Associations in Homooligomeric Proteins.
作者信息
Wodak Shoshana J, Malevanets Anatoly, MacKinnon Stephen S
机构信息
Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; VIB Structural Biology Research Center, Brussels, Belgium.
Cyclica, Inc., Toronto, Ontario, Canada.
出版信息
Biophys J. 2015 Sep 15;109(6):1087-100. doi: 10.1016/j.bpj.2015.08.010. Epub 2015 Sep 1.
Abstract
We present an overview of the full repertoire of intertwined associations in homooligomeric proteins. This overview summarizes recent findings on the different categories of intertwined associations in known protein structures, their assembly modes, the properties of their interfaces, and their structural plasticity. Furthermore, the current body of knowledge on the so-called three-dimensional domain-swapped systems is reexamined in the context of the wider landscape of intertwined homooligomers, with a particular focus on the mechanistic aspects that underpin intertwined self-association processes in proteins. Insights gained from this integrated overview into the physical and biological roles of intertwining are highlighted.
摘要
我们概述了同源寡聚蛋白中相互缠绕关联的全部类型。本概述总结了已知蛋白质结构中不同类型相互缠绕关联的最新研究结果、它们的组装模式、界面特性及其结构可塑性。此外，在更广泛的相互缠绕同源寡聚体背景下重新审视了目前关于所谓三维结构域交换系统的知识体系，特别关注支撑蛋白质中相互缠绕自组装过程的机制方面。强调了从这一综合概述中获得的关于相互缠绕的物理和生物学作用的见解。
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