执行功能测量表现各异的患者的诊断概况。
Diagnostic Profiles of Patients Differentially Failing Executive Functioning Measures.
作者信息
Hammers Dustin, Ramirez Gabriela, Persad Carol, Heidebrink Judith, Barbas Nancy, Giordani Bruno
机构信息
Department of Neurology, Center for Alzheimer's Care, Imaging, and Research, University of Utah, Salt Lake City, UT, USA
Neuropsychology Section, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2016 May;31(3):214-22. doi: 10.1177/1533317515603114. Epub 2015 Sep 3.
OBJECTIVE
Limited research exists to explain differential executive functioning impairment in clinical populations, particularly between the Wisconsin Card Sorting Task (WCST) and the Trail Making Test (TMT).
METHODS
The distribution of clinical diagnoses was examined in patients failing none, one, or both tasks, and executive task performance was compared among dementia-related diagnoses. Two hundred and sixty-six participants received evaluations through an Alzheimer's Disease Research Center, which included executive tasks. Dementia-related diagnoses were established through consensus.
RESULTS
Chi-square analyses indicated that TMT failure, with or without WCST failure, possessed higher associations with dementia diagnoses. Repeated measures analysis of variance similarly indicated that participants with dementia, especially mild and moderate severity, performed worse on TMT.
CONCLUSIONS
Executive dysfunction was observed in dementia-related diagnoses, and TMT failure was implicated in dementia in higher proportions than WCST impairment. Trail Making Test appears more sensitive than WCST for assessing executive impairment across diagnoses, especially when time and resources are limited in screening and clinical settings.
目的
现有研究有限，难以解释临床人群中不同的执行功能损害情况，尤其是在威斯康星卡片分类测验（WCST）和连线测验（TMT）之间的差异。
方法
对未完成任何一项任务、仅未完成一项任务或两项任务均未完成的患者的临床诊断分布进行了检查，并比较了与痴呆相关诊断之间的执行任务表现。266名参与者通过阿尔茨海默病研究中心接受了评估，其中包括执行任务。通过共识确定了与痴呆相关的诊断。
结果
卡方分析表明，无论WCST是否失败，TMT失败与痴呆诊断的关联度更高。重复测量方差分析同样表明，患有痴呆症的参与者，尤其是轻度和中度严重程度的参与者，在TMT上的表现更差。
结论
在与痴呆相关的诊断中观察到执行功能障碍，与WCST损害相比，TMT失败在痴呆症中的比例更高。在评估各种诊断中的执行功能损害时，连线测验似乎比威斯康星卡片分类测验更敏感，尤其是在筛查和临床环境中时间和资源有限时。
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