与抗N-甲基-D-天冬氨酸受体脑炎相关的小儿眼阵挛-肌阵挛-共济失调综合征
Pediatric Opsoclonus-Myoclonus-Ataxia Syndrome Associated With Anti-N-methyl-D-aspartate Receptor Encephalitis.
作者信息
Player Brittany, Harmelink Matthew, Bordini Brett, Weisgerber Michael, Girolami Michael, Croix Michael
机构信息
Pediatric Hospital Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Pediatric Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.
出版信息
Pediatr Neurol. 2015 Nov;53(5):456-8. doi: 10.1016/j.pediatrneurol.2015.07.010. Epub 2015 Aug 1.
BACKGROUND
The full clinical spectrum of anti-N-methyl-D-aspartate receptor encephalitis is unknown in the pediatric population.
PATIENT
We describe a previously healthy 4-year-old girl presenting with opsoclonus-myoclonus together with ataxia who had NR1-specific, anti-N-methyl-D-aspartate receptor antibodies in the cerebral spinal fluid.
CONCLUSION
The presence of NR1-specific, anti-N-methyl-D-aspartate receptor antibodies in the setting of opsoclonus-myoclonus and ataxia syndrome may represent an expansion of the clinical presentations of anti-N-methyl-D-aspartate receptor encephalitis.
背景
抗N-甲基-D-天冬氨酸受体脑炎在儿科人群中的完整临床谱尚不清楚。
患者
我们描述了一名此前健康的4岁女孩，出现眼阵挛-肌阵挛伴共济失调，其脑脊液中存在NR1特异性抗N-甲基-D-天冬氨酸受体抗体。
结论
在眼阵挛-肌阵挛和共济失调综合征背景下出现NR1特异性抗N-甲基-D-天冬氨酸受体抗体可能代表抗N-甲基-D-天冬氨酸受体脑炎临床表现的扩展。
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