Department of Pediatric Neurology, P.D. Hinduja Hospital, Mumbai, Maharashtra, India.
Pediatr Neurol. 2012 Apr;46(4):246-9. doi: 10.1016/j.pediatrneurol.2012.01.012.
A rare, severe form of immune-mediated encephalitis recently has been described, associated with antibodies against N-methyl-D-aspartate receptors. It is reported mostly in women with ovarian tumors. Nonparaneoplastic presentations are less common. We describe four children with a neuropsychiatric and extrapyramidal syndrome associated with the presence of anti-N-methyl-D-aspartate receptor antibodies in cerebrospinal fluid and serum, without evidence of neoplasia. Three children recovered completely after immunomodulatory therapy, i.e., intravenous immunoglobulin and/or steroids, methylprednisolone, and/or adrenocorticotrophic hormone.
最近描述了一种罕见且严重的免疫介导性脑炎，与抗 N-甲基-D-天冬氨酸受体抗体有关。它主要发生在卵巢肿瘤的女性中。非副肿瘤表现则较为少见。我们描述了 4 例儿童出现神经精神和锥体外系综合征，伴有脑脊液和血清中存在抗 N-甲基-D-天冬氨酸受体抗体，但没有肿瘤证据。3 例患儿在免疫调节治疗后完全康复，即静脉注射免疫球蛋白和/或类固醇、甲基强的松龙和/或促肾上腺皮质激素。
