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婴幼儿及学龄前儿童肾结石的微创经皮肾镜取石术结果:一项前瞻性研究

Outcome of Mini-percutaneous Nephrolithotomy for Renal Stones in Infants and Preschool Children: A Prospective Study.

作者信息

Daw Kareem, Shouman Ahmed M, Elsheemy Mohammed S, Shoukry Ahmed I, Aboulela Waseem, Morsi Hany A, Badawy Hesham, Eissa Mohamed A

机构信息

Division of Pediatric Urology, Aboul-Riche Children's Hospital, Cairo University, Cairo, Egypt.

Division of Pediatric Urology, Aboul-Riche Children's Hospital, Cairo University, Cairo, Egypt.

出版信息

Urology. 2015 Nov;86(5):1019-26. doi: 10.1016/j.urology.2015.08.019. Epub 2015 Sep 2.

Abstract

OBJECTIVE

To assess the safety and efficacy of Miniperc for renal stones in preschool-age patients. To the best of our knowledge, this may be the first prospective study on this subject. Reports on Miniperc are still few and mostly retrospective using a sheath size of ≥ 18Fr, which is still relatively large for young children.

PATIENTS AND METHODS

From January 2012 to May 2013, Miniperc was performed for 26 children (≤ 6 years old) with renal calculi <5 cm through 14Fr sheath using a 9.5Fr semirigid ureteroscope with Holmium:yttrium-aluminum-garnet laser lithotripsy. Effects of different factors on operative time, complications, and stone-free rate (SFR) were compared using chi-square, Fischer exact, or Mann-Whitney tests as appropriate using SPSS v15.0.

RESULTS

Primary SFR, SFR after retreatment, and SFR after auxiliary extracorporeal shock wave lithotripsy (ESWL) were 77%, 85%, and 92%, respectively. Retreatment rate was 8%. Auxiliary ESWL was done in 11%. Complications were bleeding (8%), hematuria and blood transfusion (4%), renal pelvis perforation (4%), leakage (8%), and fever (15%). Operative time was significantly prolonged in multiple (>2) stones (P = .006), calyceal stones (P = .002), or stone size ≥ 30 mm (P = .022). SFR was significantly lower in children with >2 stones (P = .028) and increased stone size ≥ 30 mm (P = .014).

CONCLUSION

Miniperc is a safe and effective minimally invasive procedure for pediatric renal stones using 14Fr access sheath. SFR was significantly lower in children with >2 stones or increased stone size ≥ 30 mm. This was overcome by retreatment and auxiliary ESWL.

摘要

目的

评估Miniperc技术用于学龄前儿童肾结石治疗的安全性和有效性。据我们所知,这可能是关于该主题的第一项前瞻性研究。关于Miniperc技术的报道仍然很少,并且大多是回顾性研究,使用的鞘管尺寸≥18Fr,这对于幼儿来说仍然相对较大。

患者与方法

2012年1月至2013年5月,对26例年龄≤6岁、肾结石<5 cm的儿童,通过14Fr鞘管,使用9.5Fr半硬性输尿管镜及钬:钇铝石榴石激光碎石术进行Miniperc手术。使用SPSS v15.0软件,根据情况采用卡方检验、Fisher精确检验或Mann-Whitney检验,比较不同因素对手术时间、并发症及结石清除率(SFR)的影响。

结果

初次结石清除率、再次治疗后的结石清除率及辅助体外冲击波碎石术(ESWL)后的结石清除率分别为77%、85%和92%。再次治疗率为8%。11%的患者接受了辅助ESWL治疗。并发症包括出血(8%)、血尿及输血(4%)、肾盂穿孔(4%)、漏尿(8%)和发热(15%)。多颗(>2颗)结石(P = .006)、肾盏结石(P = .002)或结石大小≥30 mm(P = .022)时,手术时间显著延长。结石>2颗的儿童(P = .028)及结石大小≥30 mm(P = .014)时,结石清除率显著降低。

结论

Miniperc技术使用14Fr通道鞘管治疗小儿肾结石是一种安全有效的微创手术。结石>2颗或结石大小≥30 mm的儿童结石清除率显著较低。通过再次治疗和辅助ESWL可克服这一问题。

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