地方性流行区的家族性肝细胞癌：两例病例报告
Familial hepatocellular carcinoma in an endemic area: two case reports.
作者信息
Weledji Elroy P, Nsagha Dickson S, Enoworock George, Mouladje Maurice
机构信息
Department of Surgery, Faculty of Health Sciences, University of Buea, PO Box 126, Limbe, S.W. Region, Buea, Cameroon.
Department of Public Health, Faculty of Health Sciences, University of Buea, Buea, Cameroon.
出版信息
BMC Res Notes. 2015 Sep 5;8:415. doi: 10.1186/s13104-015-1366-7.
BACKGROUND
Hepatocellular carcinoma (HCC) usually affects patients aged 50-70 years but earlier onset (25-40 years) may occur in hepatitis B endemic areas. 70-90% of HCC develop on a background of cirrhosis. However, hepatitis B virus is directly oncogenic and can cause HCC in the absence of cirrhosis. This may represent a major cause of death from late diagnosis in resource-limited areas.
CASE PRESENTATION
We report a black African family in which clinical diagnosis of HCC was made on two male siblings in the south west region of Cameroon.
CONCLUSIONS
The highest risk for HCC may occur in families in which a hereditary component may be acting in concert with hepatitis B virus. In all cases of HCC, it is important to screen all first degree relatives to detect early and asymptomatic disease.
背景
肝细胞癌（HCC）通常影响50至70岁的患者，但在乙肝流行地区可能出现更早发病（25至40岁）。70%至90%的HCC发生在肝硬化背景下。然而，乙肝病毒具有直接致癌性，可在无肝硬化的情况下导致HCC。这可能是资源有限地区因诊断延迟导致死亡的主要原因。
病例报告
我们报告了一个来自喀麦隆西南部地区的黑人非洲家庭，该家庭中的两名男性兄弟姐妹被临床诊断为HCC。
结论
HCC的最高风险可能发生在遗传因素与乙肝病毒共同作用的家庭中。在所有HCC病例中，对所有一级亲属进行筛查以检测早期无症状疾病非常重要。
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