Kott J N, Kenney N J, Bhatia A J, Bhatia A M
Department of Psychology, University of Washington, Seattle, WA 98195.
Physiol Behav. 1989 Dec;46(6):971-6. doi: 10.1016/0031-9384(89)90200-x.
The effects of daily administration of protamine zinc insulin (PZI) on plasma insulin and glucose levels and on food intake and body weight of rats with lesions of the area postrema and adjacent caudal-medial portions of the nucleus of the solitary tract (APX rats) were examined. Prior to insulin treatment, APX rats weighted less and had lower plasma immunoreactive insulin (IRI) levels than nonlesioned controls but did not differ from controls in plasma glucose levels. Five daily injections of 5 U/kg PZI raised plasma IRI and lowered plasma glucose levels similarly for both lesioned and nonlesioned rats. When injected with increasing doses of PZI over a 30-day period, both lesioned and nonlesioned rats showed increases of food intake and rate of weight gain in response to 8 U/kg PZI. These data indicate that APX does not affect either physiological or behavioral responses to chronic peripheral insulin administration.
研究了每日给予精蛋白锌胰岛素（PZI）对孤束核最后区及相邻尾内侧部分损伤的大鼠（APX大鼠）的血浆胰岛素和葡萄糖水平、食物摄入量及体重的影响。在胰岛素治疗前，APX大鼠体重比未损伤的对照组轻，血浆免疫反应性胰岛素（IRI）水平也较低，但血浆葡萄糖水平与对照组无差异。每日注射5 U/kg的PZI，连续注射5天，损伤组和未损伤组大鼠的血浆IRI均升高，血浆葡萄糖水平均降低。在30天内注射递增剂量的PZI时，损伤组和未损伤组大鼠在注射8 U/kg PZI后均出现食物摄入量增加和体重增加速率加快的情况。这些数据表明，APX并不影响对慢性外周胰岛素给药的生理或行为反应。
